MMC100新陳代謝籠用于小鼠的實驗，是一個獨立的單元，設(shè)計用于單個小鼠的長達(dá)24小時的實驗。該代謝籠具有獨特的功能，可以最大程度的減少尿液收集的污染。

MMC100新陳代謝籠由不銹鋼和丙烯酸制成，有以下的8個組件：
1  頂部圓筒
2  底部圓筒 
3  底板
4  收集漏斗
5  蓋子
6  喂食器

收集步驟:
新陳代謝籠的高效收集的關(guān)鍵在于收集漏斗。它收集小鼠的尿液小滴，使之慢慢的聚集到中間的球狀物上，直到足夠多后就會滴落到下面的收集容器中。任何的雜質(zhì)，即使沒有被底板排除在外，也會被漏斗排除在外，使雜質(zhì)不會進(jìn)入到收集容器中,得到完整、清潔的樣品。

肥胖設(shè)計:
肥胖的設(shè)計和標(biāo)準(zhǔn)的代謝籠有一個區(qū)別：在頂部的圓筒上的臂是45?角的，以便于安裝超重小鼠的喂食和喂水器。肥胖的設(shè)計包括先前提到的標(biāo)準(zhǔn)設(shè)計相同的功能。此外，雖然最初是為肥胖小鼠設(shè)計的，但是這個籠子也可以適用于標(biāo)準(zhǔn)的小鼠。

冷卻系統(tǒng)設(shè)計:
冷卻系統(tǒng)分為兩部分，包括絕緣籠基座和連接到冷卻系統(tǒng)的基座插頭。 這個籠子提供了一個方便的方法去保持整個收集過程中的樣品溫度在或低于45?F（7?C）。

1    易于使用、安裝和清潔
2    精確的從糞便中分離尿液
3    很少的組成結(jié)構(gòu)和耗材
4    由堅固耐用的丙烯酸材料制作
5    不銹鋼材料的底板和收集漏斗  
6    O形環(huán)密封圈用于剛性連接    
7    透明設(shè)計，便于觀察  
8    提供24小時、2-5ml的收集 
9    尿液收集容器是可移動的
10  符合實驗動物使用和護(hù)理的要求 
11  可選的肥胖和冷卻系統(tǒng)設(shè)計

1    易于使用、安裝和清潔
2    精確的從糞便中分離尿液
3    很少的組成結(jié)構(gòu)和耗材
4    由堅固耐用的丙烯酸材料制作
5    不銹鋼材料的底板和收集漏斗 
6    O形環(huán)密封圈用于剛性連接
7    透明設(shè)計，便于觀察 
8    提供24小時、2-5ml的收集
9    尿液收集容器是可移動的
10  符合實驗動物使用和護(hù)理的要求
11  可選的肥胖和冷卻系統(tǒng)設(shè)計

新陳代謝籠可用于多種研究，包括（但不僅僅限于）：
1 藥物治療的效果  
2 腎功能的研究
3 尿蛋白排泄
4 每日攝入的食物和水
5 表型
6 評價標(biāo)準(zhǔn)或干預(yù)的代謝功能
7 尿排泄量
該代謝籠也可以改良成用于肥胖小鼠，或者/和包含一個絕緣的基座以鏈接CCS2000冷卻系統(tǒng)。

KynurenineInfusion Disrupts Normal Blood Pressure Circadian Rhythms

DebraL IrsikW.BollagC.Isales

Biology, Medicine

The FASEB Journal   1 May 2022

The data suggest that kynurenine treatment impacts renalfunction and may contribute to the development of CKD, a significant riskfactor for cardiovascular disease, even in the context of normotension.

Changes inOxygen Consumption and Metabolomic Profiles in the Kidney of Sprague‐Dawley Rat fed a High‐Salt Diet

S.ShimadaBrianR. HoffmannAndrewS. GreeneMingyuLiangR.DashA.Cowley

Medicine, Biology

The FASEB Journal  1May 2022

It is concluded that a high‐salt diet increases oxygenconsumption and alters the metabolomic profiles of the kidney.

Toward the InterdisciplinaryTheory and Research

O.Yanitsky

Creative Education  6 March 2020

The article represents some thoughts and considerationson an interdisciplinary theory and research based on the relevant scientificworks and the author’s personal and “big family” experience and…

Toward theInterdisciplinary Theory and Research

AixaHafsha  19 April 2020

The article represents some thoughts and considerationson an interdisciplinary theory and research based on the relevant scientificworks and the author’s personal and “big family” experience and… 

High Salt DietIncreases Renal Oxygen Consumption in Sprague‐Dawley Rats

S.ShimadaR.DashA.Cowley

The FASEB Journal  1May 2021

It appears that in normal SD rats, the increased tubular metabolic workassociated with a high salt diet is initially accommodated by increasedperfusion (RBF) and a gradual increase of O2 consumption while extractionremains unchanged for a two‐week period.

Chronic RenalArtery Insulin Infusion Decreases 24 hr/day Renal Blood Flow in Diabetic Rats

M.BrandsW.Bush   Medicine, Biology

The FASEB Journal  1May 2021

A chronic renal vasoconstrictor influence of insulinunder diabetic conditions is suggested, which suggests that the decrease ininsulin may contribute directly to the renal vasodilation that occurs in type 1diabetes.

M.CrostelliO.MazzaM.MarianiD.MascelloC.Iorio

International Orthopaedics 14 September 2018

Bracing is a viable treatment strategy in thoracic lumbarkyphosis and can obtain good clinical results at medium terms follow-up even ifkyPHosis deformity remains in radiographs, as even smallest devices availableare often too big.

Precise Controlof Target Temperature Using N6-Cyclohexyladenosine and Real-Time Control ofSurface Temperature.

B.LaughlinI.BaileyS.RiceZ.BaratiLoriK. BogrenK.Drew

Therapeutic Hypothermia and Temperature…1 June 2018

An intravenous delivery protocol for CHA at 0.25mg/(kg·h) that, when coupled with conductive cooling, achievesand maintains a prescribed and consistent target Tb between 32°Cand 34°C for 24 hours.

Physiologicalhyperinsulinemia caused by acute hyperglycemia minimizes renal sodium loss bydirect action on kidneys.

DebraL IrsikM.Brands

Medicine, Biology American Journal of Physiology.Regulatory…  23 May 2018

The hypothesis that meal-induced increases in plasmainsulin are a major component of normal sodium homeostasis, and that thisoccurs by direct action of insulin on the kidney is supported.

The normalincrease in insulin after a meal may be required to prevent postprandial renalsodium and volume losses.

DebraL IrsikB.Blazer-YostA.StaruschenkoM.Brands

Medicine, Biology

American Journal of Physiology. Regulatory…   1 June 2017

It is demonstrated that the normal increase incirculating insulin in response to hyperglycemia may be required to preventexcessive renal sodium and volume losses and suggested that insulin may be a physiologicalregulator of sodium balance.